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the inventors have discovered certain novel small molecule NNMT inhibitors and have developed methods for preparing these molecules

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And the effects persist after discontinuation because the cellular repairs it initiates are structural, not temporary

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doi: 10.1016/j.cbi.2023.110607 176 TangYLuoHXiaoQLiLZhongXZhangJet al

Deficiency can occur in certain populations, including older adults, vegans, individuals with pernicious anaemia, those with malabsorption disorders such as Crohn's disease or coeliac disease, people who have had bariatric surgery or gastrectomy, and those on long-term medication such as metformin or acid-suppressing drugs